Topic for October: HLA class II across TCGA cancer dataset

In October, the CGC Webinar Series featured a talk by Dr. Pascal Belleau. Dr. Belleau is a computational biology postdoctoral fellow in Krasnitz Laboratory, at the Quantitative Biology Department of Cold Spring Harbor Laboratory.

In this webinar, Dr. Belleau discussed HLA class II across The Cancer Genome Atlas dataset. The HLA class II complex is an essential molecular component of adaptive immunity in general, and of immune response to cancer. Using the Cancer Genomics Cloud, Dr. Belleau performed HLA class II typing across the entire TCGA collection of approximately 11,000 patient samples spanning 33 tumor types. Additionally, he investigated HLA class II pattern intra- and inter-different cancer types. The aim of this research is to clarify how HLA class II mediates immune response to cancer.

Dr. Pascal Belleau, postdoctoral fellow at Cold Spring Harbor Laboratory